Dolutegravir: clinical efficacy and role in HIV therapy
نویسندگان
چکیده
منابع مشابه
The role of dolutegravir in the management of HIV infection
Dolutegravir is the most recent integrase strand transfer inhibitor approved for HIV-1 infection in both treatment-naïve and experienced patients. As a tricyclic carbamoyl pyridone analog, dolutegravir is rapidly absorbed and distributes through the cerebrospinal fluid. It is hepatically metabolized by uridine diphosphate glucuronosyl transferase 1A1; no inhibition or induction of cytochrome P4...
متن کاملClinical effectiveness of dolutegravir in the treatment of HIV/AIDS
Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI), which has now been licensed to be used in different countries including the UK. Earlier studies have demonstrated that DTG when used with nucleoside backbone in treatment-naïve and - experienced patients has been well tolerated and demonstrated virological suppression comparable to other INSTIs and superiorit...
متن کاملLamivudine/dolutegravir dual therapy in HIV-infected, virologically suppressed patients
BACKGROUND Little is known about the applicability of dual treatments based on integrase inhibitors. We explored the combination of lamivudine + dolutegravir as an option when switching from standard cART in virologically suppressed patients. METHODS In this prospective cohort we enrolled patients previously switched to 3TC + DTG who were 18 years or older, with no previous resistance mutatio...
متن کاملDolutegravir – a review of the pharmacology, efficacy, and safety in the treatment of HIV
Dolutegravir is the newest integrase strand transfer inhibitor to be approved for the treatment of human immunodeficiency virus (HIV) infection. Dolutegravir is equivalent or superior to existing treatment regimens in both treatment-naïve and treatment-experienced patients including those with previous raltegravir or elvitegravir failure. The consistent efficacy coupled with excellent tolerabil...
متن کاملDolutegravir-based anti-retroviral therapy is effective and safe in HIV–infected paediatric patients
BACKGROUND Treatment of HIV infection in adolescents is challenging due to long duration of therapy and poor adherence. Recently, the integrase strand transfer inhibitor dolutegravir (DTG) has been approved for the use in adolescents with HIV, but evidence in clinical practice is very limited. METHODS We describe six cases of HIV-infected children/adolescents successfully treated with DTG-bas...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Chronic Disease
سال: 2014
ISSN: 2040-6223,2040-6231
DOI: 10.1177/2040622314530461